Ingredient
Adapalene
Adapalene is a topical retinoid available over the counter in some countries (including the US and Canada) and pharmacy-only or prescription elsewhere.
INCI: Adapalene
Part of: Retinoids
How it works
It normalises skin cell turnover inside pores, which may help with whiteheads, blackheads and ongoing breakouts over several weeks.
Typical strengths: 0.1% gel is standard OTC in the US. Some markets also offer 0.3% under professional supply.
How people use it
- 0.1% gel is the most common consumer strength
- Evening use, often every second night at first
- Thin layer on dry skin after cleansing
- Moisturiser after it absorbs; SPF every morning
Who it may suit
May suit
- Comedonal acne (blackheads and whiteheads)
- People starting a retinoid for the first time
- Maintenance after active breakouts improve
May want something else if
- Pregnancy without clinician advice
- Same-night stacking with strong benzoyl peroxide on the same areas (many people alternate)
What to watch for
- Initial dryness and peeling
- Availability and status differ by country
- Allow 8β12 weeks before judging results
Compare alternatives
Often compared with Differin alternatives, benzoyl peroxide, or prescription tretinoin.
Often discussed for
AcneSpot picks
Shortlists that include products with Adapalene.
AcneSpot picks: OTC retinoids (US)
Over-the-counter adapalene products available in the US.
πΊπΈ United StatesAcneSpot picks: acne creams (United States)
A shortlist of acne creams with United States availability in mind. Ranked by catalogue signals and updated as products are added β educational only.
πΊπΈ United StatesAcneSpot picks: serums (United States)
A shortlist of serums with United States availability in mind. Ranked by catalogue signals and updated as products are added β educational only.
πΊπΈ United States
Products with Adapalene

La Roche-Posay
La Roche-Posay Effaclar Adapalene Gel 0.1%
United StatesIn stockUSD 28β35via TargetA topical retinoid (adapalene) product; status varies by country.

Differin
Differin Adapalene Gel 0.1%
United KingdomIn stockGBP 18β22via BootsA 0.1% adapalene gel, one of the most recognised over-the-counter retinoids for acne in the US.

Dermatica
Dermatica Personalised Formula
United KingdomIn stockGBP 25β30via DermaticaA prescription-strength personalised topical formula provided via an online consultation.